This was a recipe for trouble, and many of the nostrums advertised in these almanacs contained liberal amounts of alcohol. Or of narcotics. Good marketing I suppose, it encouraged repeat customers.
The result was a fair amount of genteel tippling. Folks in "dry" counties would purchase bitters and elixirs by the case. Women who would not be caught dead in a saloon would have their daily dose of "Vegetable Compound".
Most of this was glossed over by the almanac makers, but a few hints peek through....
Here's another flavor of bad idea:
And yet another gem:
Given the potential for mood alteration inherent in many nostrums from the Golden Age of patent medicines it is entirely possible that the chap below had not been to a party, but to a drug store: